Mingrui Xia (夏明睿)

Ph.D., Professor

State Key Laboratory of Cognitive Neuroscience and Learning

Beijing Key Laboratory of Brain Imaging and Connectomics

Beijing Normal University, Beijing, China 100875

E-mail: mxia#bnu.edu.cn


Research Interests

  • Computational methods for multi-center neuroimaging big data

  • Connectome dysfunction in psychiatric disorders

  • Connectome development from childhood to adolescence

Education

  • 2010-2013: Ph.D., Beijing Normal University, Beijing, China

  • 2007-2010: M.Sc., Beihang University, Beijing, China

  • 2003-2007: B.Sc., Beihang University, Beijing, China

Professional Positions

  • 2024-present: Professor, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, China

  • 2024-present: Professor, Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, China

  • 2019-2024: Associate Professor, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, China

  • 2017-2024: Associate Professor, Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, China

  • 2016-2019: Research Associate Professor, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, China

  • 2013-2016: Research Assistant Professor, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, China

Awards

  • Replication Award, Organization for Human Brain Mapping (OHBM) (2021)

  • Most Cited Chinese Researchers, Elsevier (2020-2022)

  • World's Top 2% Scientist list, Stanford University (2019-2023)

  • Best Neuroscience Scientists, Research.com (2023)

  • Beijing Distinguished Young Scholars, Beijing Municipal Science & Technology Commission (2023)

  • Beijing Nova Scholars, Beijing Municipal Science & Technology Commission (2019)

  • Beijing Municipality for Science and Technology Awards (Second Grade), Beijing Municipal Science & Technology Commission (2014)

Services and Professional Activities

  • Professional society affiliations: Organization for Human Brain Mapping; International Society for Magnetic Resonance in Medicine; Chinese Psychological Society; Chinese Society for Cognitive Science; Chinese Society of Microcirculation.

  • Associate Editor: Progress in Neuro-Psychopharmacology & Biological Psychiatry (5y-IF: 5.3) 2024-data

  • Associate Editor: Frontiers in Neuroscience (5y-IF: 5.2) 2020-data

  • Editorial Board: CNS Neuroscience & Therapeutics (5y-IF: 6.2) 2023-data

  • Editorial Board: Neuroimage: Clinical (5y-IF: 5.1) 2023-data

  • Founding Editorial Board: PLOS Mental Health 2023-data

  • Journal Reviewer: Nat Mental Health, Nat Commun, Mol Psychiatry, Biol Psychiatry, IEEE Trans Med Imaging, EBioMedicine, Brit J Psychiatry, BMC Medicine, PLoS Biology, Neurosci Biobehav Rev, Expert Syst Appl, Elife, Epidemiol Psych Sci, Psychiatry Res, Aging Dis, Asian J Psychiatry, Psychological Med, Schizophr Bull, Depress Anxiety, Transl Psychiatry, Sci China Inform Sci, Neurotherapeutics, Current Neuropharmacology, Neuroimage, Network Comp Neural, Prog Neuropsychopharmacol Biol Psychiatry, etc.

Fundings

1.     Computational method for harmonization of multi-center magnetic resonance imaging data of children and adolescents, the Scientific and Technological Innovation 2030 - the major project of the Brain Science and Brain-Inspired Intelligence Technology, No. 2022ZD0211500, 2022-2027, Role on project: PI.

2.     Individual differences and structure-function coupling mechanisms of connectome gradient disruptions in depression, Beijing Natural Science Foundation, No. JQ23033, 2023-2026, Role on project: PI.

3.     The gray matter morphology brain structural networks in major depressive disorder with magnetic resonance imaging, National Natural Science Foundation of China, No. 82071998, 2021-2024, Role on project: PI.

4.     Alterations of brain networks in depression with multi-site imaging big data, Beijing Nova Program, No. Z191100001119023, 2019-2022, Role on project: PI.

5.     Antidepressant effects on high-resolution dynamic functional brain networks in major depressive disorder, National Natural Science Foundation of China, No. 81671767, 2017-2020, Role on project: PI.

6.     The Pivotal Circuits of Human Whole Brain Network with Multi-modal Magnetic Resonance Imaging, National Natural Science Foundation of China, No. 81401479, 2015-2017, Role on project: PI.

Selected Publications

Senior or first author articles (* corresponding authorship, # co-first authorship)

1.        Sun X, Liu J, Ma Q, Wang X, Wei D, Chen Y, Liu B, Huang CC, Zheng Y, Wu Y, Chen T, Cheng Y, Xu X, Gong Q, Si T, Qiu S, Lin CP, Cheng J, Tang Y, Wang F, Qiu J, Xie P, Li L, Wang W, He Y, DIDA-MDD Working Group, Xia M* (2023) Mapping Neurophysiological Subtypes of Major Depressive Disorder Using Normative Models of the Functional Connectome. Biol Psychiatry 94:936-47.

2.        Xia M, Liu J, Mechelli A, Sun X, Ma Q, Wang X, Wei D, Chen Y, Liu B, Huang CC, Zheng Y, Wu Y, Chen T, Cheng Y, Xu X, Gong Q, Si T, Qiu S, Lin CP, Cheng J, Tang Y, Wang F, Qiu J, Xie P, Li L, DIDA-MDD Working Group, He Y* (2022) Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes. Mol Psychiatry 27:1384-93. (ESI top 1% highly cited paper)

3.        Xia M, He Y* (2023) Connectomics reconciles seemingly irreconcilable neuroimaging findings. Trends Cogn Sci 27:512-3.

4.        Xia M, He Y* (2023) Unraveling Circuit Mechanisms of Depression Remission and Relapse Vulnerability. Biol Psychiatry 93:213-4.

5.        Wang J#, Sun L#, Chen L, Sun J, Xie Y, Tian D, Gao L, Zhang D, Xia M*, Wu Tao* (2023) Common and Distinct Roles of Amygdala Subregional Functional Connectivity in Non-Motor Symptoms of Parkinson's Disease. NPJ Parkinsons Dis 9:28.

6.        Wang L, Ma Q, Sun X, Xu Z, Zhang J, Liao X, Wang X, Wei D, Chen Y, Liu B, Huang CC, Zheng Y, Wu Y, Chen T, Cheng Y, Xu X, Gong Q, Si T, Qiu S, Lin CP, Cheng J, Tang Y, Wang F, Qiu J, Xie P, Li L, He Y, DIDA-MDD Working Group, Xia M*, Zhang Y* (2023) Frequency-resolved connectome alterations in major depressive disorder: A multi-site resting fMRI study. J Affect Disord 328:47-57.

7.        Xia Y#, Xia M#, Liu J, Liao X, Lei T, Liang X, Zhao T, Shi Z, Sun L, Chen X, Men W, Wang Y, Pan Z, Luo J, Peng S, Chen M, Hao L, Tan S, Gao JH, Qin S, Gong G, Tao S, Dong Q, He Y* (2022) Development of functional connectome gradients during childhood and adolescence. Sci Bull 67:1049-61.

8.        Tian D, Zeng Z, Sun X, Tong Q, Li H, He H, Gao JH, He Y, Xia M* (2022) A deep learning-based multisite neuroimage harmonization framework established with a traveling-subject dataset. Neuroimage 257:119297.

9.        Fan Z, Fan Z, Qiu T, Hu L, Shi Y, Xia Y, Sun X, Liu Y, Li S, Xia M*, Zhu W* (2022) Altered topological properties of the intrinsic functional brain network in patients with right-sided unilateral hearing loss caused by acoustic neuroma. Brain Imaging Behav 16:1873-83.

10.    Xia M, He Y* (2022) Connectome-guided transcranial magnetic stimulation treatment in depression. Eur Child Adolesc Psychiatry 31:1481-3.

11.    Sun X, Liu J, Ma Q, Duan J, Wang X, Xu Y, Xu Z, Xu K, Wang F, Tang Y*, He Y, Xia M* (2021) Disrupted intersubject variability architecture in functional connectomes in schizophrenia. Schizophr Bull 47(4):837-48.

12.    Chen Z#, Xia M#, Zhao Y, Kuang W, Jia Z, Gong Q* (2021) Characteristics of Intrinsic Brain Functional Connectivity Alterations in Major Depressive Disorder Patients With Suicide Behavior. J Magn Reson Imaging 54:1867-75.

13.    Ma Q#, Tang Y#, Wang F, Liao X, Jiang X, Wei S, Mechelli A, He Y, Xia M* (2020) Transdiagnostic dysfunctions in brain modules across patients with schizophrenia, bipolar disorder and major depressive disorder: a connectome-based study. Schizophr Bull 46(3):699-712.

14.    Liu J#, Xia M#, Wang X, Liao X, He Y (2020) The spatial organization of the chronnectome associates with cortical hierarchy and transcriptional profiles in the human brain. Neuroimage. 222:117296.

15.    Xia M, Womer FY, Chang M, Zhu Y, Zhou Q, Edmiston EK, Jiang X, Wei S, Duan J, Xu K, Tang Y, He Y, Wang F* (2019) Shared and distinct functional architectures of brain networks across psychiatric disorders. Schizophr Bull 45(2):450-63.

16.    Xia M#, Si T#, Sun X, Ma Q, Liu B, Wang L, Meng J, Chang M, Huang X, Chen Z, Tang Y, Xu K, Gong Q, Wang F, Qiu J, Xie P, Li L*, He Y*, Group DIDA-MDD (2019) Reproducibility of functional brain alterations in major depressive disorder: Evidence from a multisite resting-state functional MRI study with 1,434 individuals. Neuroimage 189:700-14.

17.    Qiu L#, Xia M#, Cheng B, Yuan L, Kuang W, Bi F, Ai H, Gu Z, Lui S, Huang X, He Y*, Gong Q* (2018) Abnormal dynamic functional connectivity of amygdalar subregions in untreated patients with first-episode major depressive disorder. J Psychiatry Neurosci 43(3):170112.

18.    Sha Z#, Xia M#, Lin Q, Cao M, Tang Y, Xu K, Song H, Wang Z, Wang Fei, Fox, P, Evans A, He Y* (2018) Meta-Connectomic Analysis Reveals Commonly Disrupted Functional Architectures in Network Modules and Connectors across Brain Disorders. Cereb Cortex 28(12):4179-94.

19.    Du H#, Xia M#, Zhao K#, Liao X, Yang H, Wang Y*, He Y* (2018) PAGANI Toolkit: A Parallel Graph-Theoretical Analysis Package for Brain Network Big Data. Hum Brain Mapp 39(5):1869-85.

20.    Zhang N#, Xia M#, Qiu T, Wang X, Lin CP, Guo Q, Lu J, Wu Q, Zhuang D, Yu Z, Gong F, Farrukh Hameed NU, He Y*, Wu J*, Zhou L (2018) Reorganization of cerebro-cerebellar circuit in patients with left hemispheric gliomas involving language network: A combined structural and resting-state functional MRI study. Hum Brain Mapp 39(12):4802-19.

21.    Wang X, Lin Q, Xia M*, He Y* (2018) Differentially categorized structural brain hubs are involved in different microstructural, functional, and cognitive characteristics and contribute to individual identification. Hum Brain Mapp 39:1647-63.

22.    Lu XW, Guo H, Sun JR, Dong QL, Zhao FT, Liao XH, Zhang L, Zhang Y, Li WH, Li ZX, Liu TB, He Y, Xia M*, Li LJ* (2018) A shared effect of paroxetine treatment on gray matter volume in depressive patients with and without childhood maltreatment: A voxel-based morphometry study. CNS Neurosci Ther 24:1073-83.

23.    Xia M, Si T, He Y* (2018) Imaging connectomics in depression. CNS Neurosci Ther 24(11):991-3.

24.    Liu J, Xia M*, Dai Z, Wang X, Liao X, Bi Y, He Y (2017) Intrinsic Brain Hub Connectivity Underlies Individual Differences in Spatial Working Memory. Cereb Cortex 27(12):5496-508.

25.    Wei Y, Liao X, Yan C, He Y, Xia M* (2017) Identifying topological motif patterns of human brain functional networks. Hum Brain Mapp 38(5):2734-50.

26.    Xia M, He Y* (2017) Functional Connectomics from a “Big Data” Perspective. Neuroimage 160:152-67.

27.    Sheng C#, Xia M#, Yu H, Huang Y, Lu Y, Liu F, He Y, Han Y* (2017) Abnormal global functional network connectivity and its relationship to medial temporal atrophy in patients with amnestic mild cognitive impairment. PLoS One 12:e0179823.

28.    Li Y, Wang X, Li Y, Sun Y, Sheng C, Li H, Li X, Yu Y, Chen G, Hu X, Jing B, Wang D, Li K, Jessen F, Xia M*, Han Y* (2016) Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer's Disease. Neural Plasticity 2016:4680972.

29.    Wang L, Kong Q, Li K, Su Y, Zeng Y, Zhang Q, Dai W, Xia M*, Wang G, Jin Z, Yu X, Si T* (2016) Frequency-dependent changes in amplitude of low-frequency oscillations in depression: A resting-state fMRI study. Neurosci Lett 614:105-11.

30.    Xia M, Lin Q, Bi Y, He Y* (2016) Connectomic Insights into Topologically Centralized Network Edges and Relevant Motifs in the Human Brain. Front Hum Neurosci 10:158.

31.    Du H, Liao X, Lin Q, Li G, Chi Y, Liu X, Yang H, Wang Y*, Xia M* (2015) Test-Retest Reliability of Graph Metrics in High-Resolution Functional Connectomics: A Resting-State Functional MRI Study. CNS Neurosci Ther 21:802-16.

32.    Wang L#, Xia M#, Li K, Zeng Y, Su Y, Dai W, Zhang Q, Jin Z, Mitchell PB, Yu X, He Y*, Si T* (2015) The effects of antidepressant treatment on resting-state functional brain networks in patients with major depressive disorder. Hum Brain Mapp 36:768-78.

33.    Wang Z#, Xia M#, Dai Z, Liang X, Song H, He Y*, Li K* (2015) Differentially disrupted functional connectivity of the subregions of the inferior parietal lobule in Alzheimer's disease. Brain Struct Funct 220:745-62.

34.    Xia M, Wang Z, Dai Z, Liang X, Song H, Shu N, Li K, He Y* (2014) Differentially disrupted functional connectivity in posteromedial cortical subregions in Alzheimer's disease. J Alzheimers Dis 39:527-43.

35.    Wang X#, Xia M#, Lai Y, Dai Z, Cao Q, Zhang C, Han X, Yang L, Yuan Y, Zhang Y, Li K, Ma H, Shi C, Hong N, Szeszko P, He Y, Yu X (2014) Disrupted Resting-State Functional Connectivity in Minimally Treated Chronic Schizophrenia. Schizophr Res 156 :50-156.

36.    Xia M*, Wang J, He Y* (2013) BrainNet Viewer: a network visualization tool for human brain connectomics. PLoS One 8:e68910. (ESI top 0.1% hot paper, Google Scholar citation: 3526)

37.    Wang Y#, Du H#, Xia M#, Ren L, Xu M, Xie T, Gong G, Xu N, Yang H, He Y* (2013) A hybrid CPU-GPU accelerated framework for fast mapping of high-resolution human brain connectome. PLoS One 8:e62789.

38.    Xia M, He Y* (2011) Magnetic resonance imaging and graph theoretical analysis of complex brain networks in neuropsychiatric disorders. Brain Connect 1:349-65.

See Google Scholar for more publications: https://scholar.google.com/citations?hl=en&user=S5oO_zMAAAAJ

Published Software

1.        BrainNet Viewer: http://www.nitrc.org/projects/bnv/ (first author)

2.        GRETNA: http://www.nitrc.org/projects/gretna/ (co-author)

3.        PAGANI: https://www.nitrc.org/projects/pagani_toolkit/ (co-first author)

4.        SeeCAT: http://www.nitrc.org/projects/seecat/ (first author)

5.        DeRed: https://github.com/DezhengTian/DeRed-Harmonization (last author)